Scientific Name: Danio rerio
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Actinopterygii-> Actinopteri-> Neopterygii-> Teleostei-> Osteoglossocephalai-> Clupeocephala-> Otomorpha-> Ostariophysi-> Otophysi-> Cypriniphysae-> Cypriniformes-> Cyprinoidei-> Danionidae-> Danioninae-> Danio
Summary: This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_1003 | 2017.09 | Smart-seq2 | KidneyMarrow | Normal | 245 | Link |
| Vthunter_1020 | 2018.11 | Smart-seq2 | Gut | Normal | 252 | Link |
| Vthunter_110071 | 2019.12 | MARS-seq | TotalBrain | Normal | 1920 | Link |
Featureplot of receptors
Expression: Ubiquitous expression in fat (RPKM 5.6), lymph node (RPKM 3.6) and 24 other tissues
